ADInstruments POWER LAB Systems Available for Windows and MAC The Universal Digital Polygraph which can manage a complete Laboratory: Isolated Organs, Cardiovascular, Spirometry, ECG, EEG, Sport Medicine, Education, etc. etc. click here for more information
DEMO CD available showing all the almost infinite capabilities of ADI (Power Lab) Systems Ask for it, play with the real program functions and you’ll never give up

TRANSONIC - Research Perivascular and Tubing Flow meters
			Simplicity, Versatility, and Accuracy Patented in 1983, Transonic Systems' innovative ultrasonic transit-time technology has been the gold standard for volume flow measurement for more than two decades. Measurements with Transonic flowmeters have been independently validated in many applications and referenced in over 3,000 publications including more than 600 publications involving rats and mice.
Code T402-PP 2 Channel Flow Meter Perivascular Code T402-PT 1 Channel Perivasc. + 1 Ch. Tubing Code T402-TT 2 Channel Flow Meter Tubing		Code T402-PB 1 Chan. Perivascular + 1 Ch. Blank Code T402-TB 1 Channel Tubing. + 1 Ch. Blank 3 Channels FlowMeters console available

TS 420 Perivascular Module Transonic Systems' hallmark simple plug & play TS420 Flow Modules offer an unmatched range of precision flowprobes for vessels 0.25 mm and larger; a spectrum of applications including cardiac output and cardiovascular dynamics, renal hypertension, carotid thrombosis and stroke models, hemorrhagic shock, ischemia/reperfusion, portal hypertension, and hindlimb studies. - Accurately measures volume flow of less than 1 ml/min - Expanded ultrasonic frequency range for the smallest flowprobes imaginable! Implantable 0.5 mm and 0.7 mm mouse probes. - 160 Hz bandwidth to accurately characterize flow dynamics at high mouse heart rates - Analog meter displays voltage proportional to flow. - Easy access front panel receptable for chronic probe calibration keys

Transit Time Perivascular Probes Transonic Systems probes for microcirculation with Transonic flowmeters produce repeatable high resolution volumetric blood flow measurements on vessels as small as 250 micron diameter, but also in vessels as large as 1000 microns.. Choosing the appropriate series, size and style probe for your application will enhance the absolute accuracy of the flow measurement. Big size probes available for vessels up to 20 mm.

	Perivascular Probe selection Code = MA XX Y Where instead of “XX” you have to insert the desired probe size in steps starting from 0,25 mm diameter up to 20 mm. Instead of “Y” you have to insert the selectedcable exit type where B = Back or S = side (lateral)
Probes can then present different types of reflectors and closing systems around the vessels. Easier to let us know the purpose of your experiment (vessel to be measured, animal used, weight of the animal, etc. and we will provide a list of suitable probes among them you can select the most appropriate ones.

TS410 Tubing Flowmeter - In Vitro & Extracorporeal Applications Transonic Systems' TS410 Flowmeter Module with PXL-Series sterile tubing flowsensors is the system of choice for unparalleled volume flow measurements in tubing applications including extracoporeal shunts and cannulas, fluid phantoms and mock circulatory models, artificial heart and VAD performance, pulse duplication/heart valve studies and isolated perfused organ studies. The TS410 has: - Programmable calibration for different liquids. - Lowest signal-to-tubing ratio ever for tubing flow measurement. - Programmable gain for user calibration with different fluid/temperatures. - Programmable alarms: low/high flow; received signal threshold alarm - Easy-to-read numeric LED displays set-up/system status

IN-LINE PX probes In-Line probes(PX Series) for module TS410 are available in different sizes starting from 1,2 up to 25 mm diameter .

TUBING XL probes Tubing probes(XL Series) are available in different sizes from 4 up to 25 mm according to the tube which has to be used.

Specify Fluid (blood, water, etc.), temperature and Flow rate when ordering In-Line or Tubing Probes

Click here for more information

LASER DOPPLER FLOW-METERS

TRANSONIC Laser Doppler Unit Transonic’s BLF22 Series Tissue Perfusion Monitors measure microcirculation, including mass and velocity, for real-time assessment of perfusion. Tissue Perfusion Monitors can be used to monitor the effects of exercise, drug treatments, environmental or physical manipulations on target microvascular beds. A wide range of compatible Laser Doppler Probes for acute or chronic use measure perfusion, mass and velocity in 1 mm3 of tissue. Click here for more information

Code RD CF - Constant Flow Model Code RD CP - Constant Pressure Model Code RD WK – Working Heart System Re-circulating models available

Langendorff Modular Systems Isolated Heart Perfusion The Langendorff Isolated Heart Perfusion Systems permits the researcher to create constant flow or constant Pressure or WORKING HEART Langendorff preparations. The system may be placed or spontaneously beating. The system can be instrumented to measure left ventricular pressure, apical force using the built-in pulley system and coronary resistance, as well as surface fluorescence, luminescence and absorption. This type of system is often used for dose response studies in pharmacology. Its compact design has been used to introduce the heart into NMR chambers or other restricted areas. The heart chamber, components, and perfusate lines are water-jacketed for temperature control. The system is color coded for easy assembly and features charts with basic protocols and instructions. Recommended when measurements of actual cardiac work or cardiac efficiency are necessary, such as in metabolic or transgenic studies. Accessories: ED 13 – Heating and Circulating Bath MX - Dual Channel Peristaltic Pumps Electro Stimulators and electrodes

Isolated Organ Bath - Ideal for teaching, doing its simplicity to be cleaned and handled - Mounted on a Perspex chassis with two fixing holes, where the stand is located - It can be mounted, side by side, as many units as necessary. Standard stand: up to 6 units. - A water thermoregulated pump (not included) must to be used to heat the organ bath. • This pump is able to heat up to six units. - Three -way Teflon key for filling & emptying Code LE 11-100 One chamber with Thermoregulator Code LE 11-200 Two chambers with Thermoregulator Code LE 11-400 Four chambers with Thermoregulator

Compact series Isolated Organ Bath The main perspex reservoir houses the heater system, the chambers and coils, all submerged in thermostatetically controlled water. The water heating is controlled by an external unit, supplied with each system. Two basic models: A - Manual Emptying & Filling System through a 3-way teflon key : Code LE 01.00X (X = 2, 4, 6 or 8 chambers) B - Automatic Emptying & Filling System through electrovalves operated manually by keys or remote controlled by a PC or Programmer: Code LE 01.0X6 (X = 2, 4, 6 or 8 chambers) - Assembly on the front side (space saving) - Chambers & Coils removable by pressure (totally interchangeable and easy to clean) - Individual air bubbling with high precision regulation through a porous diffuser - Possibility of working by overflowing or by total emptying of the chamber - Proportional heating gradient of the heater system: avoids thermal inertia

- Heated water circulation without turbulence - Security water level sensor - Additional air outlet for the external tissue reservoir - Inflow of the physiological salt solution is done through rear connectors for each coil separately: allows the use of different solutions in each chamber

To view ELECTRIC STIMULATORS click here

HEATING BATH Internal/External Circulation A wide range of Int/Ext. Circulation heating baths for any demands, also available with refrigeration. Digital thermostat adjustment with resolution in steps of 0.1°C, capacity from 2 liters up to 25 liters, heating power from 500 W up to 3000W. Code ED5 Capac. 5 lt. Range 20-100°C Pump 15 l/min Code EH13 Capac 13 lt. Range 20-150°C Pump 15 l/min Code EH19 Capac. 19 lt. Ran. 20-150°C Pump 15 l/min A wide range of models available

Refrigerating Bath –Cryostat with Internal/External circulation A wide range of Cryostat Bath reaching up to 50 °C below zero. Powerful circulating pump for external requirements. Code F12ED Capac. 4,5 lt. Range -20 +100°C Pump 15 l/min (for temperature below 0°C use special additive t) Code F34EH Capac. 20 lt. Range -25 +150°C Pump 15 l/min (for temperature below 0°C use special additive) Code FP40MC Capac. 16 lt. Range -40 +200°C Pump 15 l/min (for temperature below 0°C use special additive) Code FP50HL Capac. 8 lt. Range -50 +200°C Pump 15 l/min (for temperature below 0°C use special additive) Code 8 940 114 Special additive liquid for low temperature operation up to 20°C below zero (bottle of 10 liters) Code 8 940 106 Special additive liquid for low temperature operation up to 40°C below zero (bottle of 10 liters)

Heating Immersion Circulators, Bridge Mounted Circulator Open Heating Bath Circulators, Heating Circulators with Open Bath Refrigerated/Heating Circulators - High Temperature Circulators Cryo-Compact Circulators - Ultra-Low Refrigerated Circulators A wide range of Baths are available Ask for for a dedicated quote according to your needs

TRANSDUCERS Code FORT 25 High Sensitivity Isometric Force Transducer 10 mg – 25 g Range Code FORT 100 Isometric Force Transducer 1 – 100 gram Range Code DSPL Isotonic Transducer for displacement recording Code CELS Temperature Probe Code LUME Light Transducer (photo-meer) Blood Pressure click here: BP Transducers

Code PNEU01 Differential Pressure Transducer. 1 psig. Code PNEU05 Differential Pressure Transducer. 5 psig. Code PNEU15 Differential Pressure Transducer. 15 psig.

HIgh Sensitivity Isometric Force Transducer A single transducer for a wide range of forces starting from just a few mg up to 25 grams. High sensitivity for small tissue such as aorta rings up to muscle of develop a force of 10 or 20 grams. Code FORT 25 High Sensitivity Isometric Force Transducer 10 mg – 25 g Range

Isotonic Displacement Transducer The Isotonic Transducer measures displacements with pre-adjusted loads (position transducer). Isotonic transducers are classically used for measuring the contraction amplitude of isolated muscles in Organ Bath studies, i.e. the changes in tissue length observed under a constant load. These transducers are preferably used with smooth muscle preparations characterized by relatively slow contractions (ileum, vas deferens, lung strips, oesophagus, urinary bladder). Code TRO 015 Isotonic Displacement Transducer

DMT Myograph Systems Examination of small Vessel/Arteries with diameters ranging from 60 micron to around 3 mm. High resolution transducers and amplifiers: Force resolution 0,01 mN. Analog output for Chart Recording or DATA Acquisition System Code 310-A Single Wire Myograph System Code 410-A Dual Wire Myograph System Code 510-A Auto Dual Wire Myograph System Code 610-M Multi Wire Myograph System System Code 120-CW Confocal Single Wire Myograph Code 120-CP Pressure Myograph System

Pressure Myograph System - 111P The Pressure Myograph is for studying pressure-diameter relations of cannulated small arteries (diameter >50µm), which can be seen through an inverted microscope. Video measurements are done of external and internal diameters through a window in the base of the Myograph with continuous display of microscope image, vessel dimensions, flow, force and temperature on monitor. Transducers continuously monitoring inflow and outflow pressures and longitudinal tension to allow standardization of arterial length using micrometer. Confocal Pressure Myograph System - 120CP The confocal pressure myograph is a system specifically for use with laser scanning confocal microscopes (LSCM) and used to study intracellular ion activity and isobaric constriction of isolated sections of small resistance arteries (diameter >50µm).

DMT Myograph Systems DMT A/S develops and produces equipments for customers with the field of cardiovascular research in both the public and private sector. The equipment is used primarily for pharmacological and physiological studies of arteries and veins. Danish Myo Technology A/S (former J.P. Trading) is a medical- and biotechnology company with more than twenty years of experience in the development and manufacture of myograph equipment designed for the in vitro assessment of vascular structure and function. Historically, myography development closely mirrors the scientific discoveries of the 1980s and 1990s when the basic mechanisms underlying the development of vascular changes in hypertension, diabetes and atherosclerosis were elucidated. Basing our designs and techniques on the methodologies of Professor M. J. Mulvany (Inst. of Pharmacology, University of Aarhus, Denmark), we have integrated the needs of the user with first class mechanical, electronical and software engineering to become one of the worlds leading designers and manufactures of wire, pressure and perfusion myographs. - Examination of small Vessel/Arteries with diameters ranging from 60 micron to around 3 mm. High resolution transducers and amplifiers: Force resolution 0,01 mN. Analog output for Chart Recording or DATA Acquisition System - Code 310-A Single Wire Myograph System - Code 410-A Dual Wire Myograph System - Code 510-A Auto Dual Wire Myograph System - Code 610-M Multi Wire Myograph System System - Code 120-CW Confocal Single Wire Myograph - Code 120-CP Pressure Myograph System

Pressure Myograph for Rapid Freezing - 115FP This pressure myograph chamber is designed for biochemical or morphological studies where rapid freezing of the vessel is frequently required. This chamber is ideal for rapid freezing of a cannulated and pressurized vessel for biochemical studies, or for quick transfer from a physiological solution into a fixative for morphological studies. The experimental chamber is made of stainless steel. A window at the base of the chamber allows the vessel dimensions to be digitized for analysis of diameter etc. The adjoining chamber, which is removable, is used for freezing or adding other fixing solutions. By raising the segment holder and thus the vessel and its tubing, the chamber stage can be moved to the side, for rapid or instant freezing or removing of the vessel segment for later analysis. This process can be done in less than a second. This chamber can be obtained as a complete setup - similiar the 110P, or as an add-on to the 110P

Pressure Myograph System - 111P The Pressure Myograph is for studying pressure-diameter relations of cannulated small arteries (diameter >50µm), which can be seen through an inverted microscope. Video measurements are done of external and internal diameters through a window in the base of the Myograph with continuous display of microscope image, vessel dimensions, flow, force and temperature on monitor. Transducers continuously monitoring inflow and outflow pressures and longitudinal tension to allow standardization of arterial length using micrometer. Intravascular pressures controlled by an easily adjustable turret with optional servo control. A heating system gives electronic feedback for maintaining organ chamber temperature above ambient temperature. The chamber cover includes ports for superfusion, for rapid draining and filling, and for gas supply. All measurements are continuously recorded by the computer.

Custom Made Glass Hardware Our Glass Laboratory can manufacture any kind of Glass Hardware according to customers’ own whishes: - Chambers of any volume and dimensions - Oxygenating Bubblers with porous frit - Pre-warming coils - Electrode and Tissue Supports Ask for more information

TISSUE SUPPORT and TISSUE MOUNTING CLIPS Code 158815-6 Tissue Support Transducer Wire 6" Long pkg of4 Code 158816 L-Shape Tissue Support for Baths Pkg of 6 (specify chamber volume) Code 158817 Tri-Shape Tissue Support for 5-10cc Baths Pkg of 12 Code 158801 Tissue Clips/Two tips meeting 8 x 14 mm pkg of 10 Code 158802 Tissue Clips/Two flat surfaces 6 x 10 mm pkg of 10

In Vivo Perfusion System InVivo Manual Gravity Perfusion Systems Steady gravity-fed delivery of buffer and fixative results in complete perfusion. Consistent results - Steady gravity-fed delivery of buffer and fixative results in complete perfusion. Easy to setup, use and clean - Complete system with everything down to the needles. Fits in standard hoods. "I can perfuse up to five animals an hour, plus it costs no more than a tube of enzyme." Dr. Yien Ming Kuo; University of California, San Francisco Code IV-140 InVivo Perfusion System 140ml – Mouse Code IV-800 InVivo Perfusion System 800ml - Rat Code IV-4140 Double InVivo Perfusion System 4x 140ml - Double Mouse

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